Check out Lowepro's latest backpacks and camera box at B&H.
The larger backpacks provide plenty of open space and feature bring-your-own padded storage. I've been using this style of pack with increasing frequency, including with Lowepro Photo Active TLZ AW Top-Loader Camera Bags.
I often carry an extremely lightweight collapsible backpack similar to the RunAbout when traveling. It makes a good emergency pack, including when forced to gate check a larger pack, and it is great when only the basics are needed (such as a lunch).