Is the Tamron 100-400mm f/4.5-6.3 Di VC USD Lens sharp? This page visually answers that question. Shown above are 100% crops from a lab-captured 100mm f/4.5 test image. Observe the contrast and resolution of these results.
Is the Tamron 100-400mm f/4.5-6.3 Di VC USD Lens set to 100mm f/4.5 sharper than the Nikon 80-400mm f/4.5-5.6G AF-S VR Lens set to 80mm f/5.0? The image quality comparison above also answers that question. Switch between the results to see the sharpness differences between these lenses.