Is the Canon EF 100-400mm f/4.5-5.6L IS II USM Lens sharp? This page visually answers that question. Shown above are 100% crops from a lab-captured 300mm f/5.6 test image. Observe the contrast and resolution of these results.
Is the Canon EF 100-400mm f/4.5-5.6L IS II USM Lens set to 300mm f/5.6 sharper than the Sigma 150-600mm f/5-6.3 DG OS HSM Sports Lens set to 300mm f/6.3? The image quality comparison above also answers that question. Switch between the results to see the sharpness differences between these lenses.